Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

BACKGROUND: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechani...

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Bibliografski detalji
Izdano u:J Neuroinflammation
Glavni autori: d’Avila, Joana Costa, Siqueira, Luciana Domett, Mazeraud, Aurélien, Azevedo, Estefania Pereira, Foguel, Debora, Castro-Faria-Neto, Hugo Caire, Sharshar, Tarek, Chrétien, Fabrice, Bozza, Fernando Augusto
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791311/
https://ncbi.nlm.nih.gov/pubmed/29382344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1059-y
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