Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

BACKGROUND: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechani...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: d’Avila, Joana Costa, Siqueira, Luciana Domett, Mazeraud, Aurélien, Azevedo, Estefania Pereira, Foguel, Debora, Castro-Faria-Neto, Hugo Caire, Sharshar, Tarek, Chrétien, Fabrice, Bozza, Fernando Augusto
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791311/
https://ncbi.nlm.nih.gov/pubmed/29382344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1059-y
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