Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

BACKGROUND: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechani...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: d’Avila, Joana Costa, Siqueira, Luciana Domett, Mazeraud, Aurélien, Azevedo, Estefania Pereira, Foguel, Debora, Castro-Faria-Neto, Hugo Caire, Sharshar, Tarek, Chrétien, Fabrice, Bozza, Fernando Augusto
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791311/
https://ncbi.nlm.nih.gov/pubmed/29382344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1059-y
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