Genetically Intact but Functionally Impaired HIV-1 Env Glycoproteins in the T-Cell Reservoir

HIV-infected subjects under antiretroviral treatment (ART) harbor a persistent viral reservoir in resting CD4(+) T cells, which accounts for the resurgence of HIV replication after ART interruption. A large majority of HIV reservoir genomes are genetically defective, but even among intact proviruses...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: de Verneuil, Anne, Migraine, Julie, Mammano, Fabrizio, Molina, Jean-Michel, Gallien, Sébastien, Mouquet, Hugo, Hance, Allan J., Clavel, François, Dutrieux, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790948/
https://ncbi.nlm.nih.gov/pubmed/29187544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01684-17
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