Natural polyreactive IgA antibodies coat the intestinal microbiota

Large quantities of immunoglobulin A (IgA) are constitutively secreted by intestinal plasma cells to coat and contain the commensal microbiota, yet the specificity of these antibodies remains elusive. Here, we profiled the reactivities of single murine IgA plasma cells by cloning and characterizing...

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Udgivet i:Science
Main Authors: Bunker, Jeffrey J., Erickson, Steven A., Flynn, Theodore M., Henry, Carole, Koval, Jason C., Meisel, Marlies, Jabri, Bana, Antonopoulos, Dionysios A., Wilson, Patrick C., Bendelac, Albert
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790183/
https://ncbi.nlm.nih.gov/pubmed/28971969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan6619
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