Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Many ion channels, including Nav1.7, Cav1.3, and Kv1.3, are linked to human pathologies and are important therapeutic targets. To develop efficacious and safe drugs, subtype-selective modulation is essential, but has been extremely difficult to achieve. We postulate that this challenge is caused by...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Chen, Jun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789920/
https://ncbi.nlm.nih.gov/pubmed/29311306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713701115
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