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A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes
Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of specific Ets partners. Chromat...
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Publicado no: | Science |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5789805/ https://ncbi.nlm.nih.gov/pubmed/22983707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228309 |
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