A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes

Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of specific Ets partners. Chromat...

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Publicado no:Science
Main Authors: Glasmacher, Elke, Agrawal, Smita, Chang, Abraham B., Murphy, Theresa L., Zeng, Wenwen, Lugt, Bryan Vander, Khan, Aly A., Ciofani, Maria, Spooner, Chauncey J., Rutz, Sascha, Hackney, Jason, Nurieva, Roza, Escalante, Carlos R., Ouyang, Wenjun, Littman, Dan R., Murphy, Kenneth M., Singh, Harinder
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789805/
https://ncbi.nlm.nih.gov/pubmed/22983707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228309
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