Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product

Malonyl-coenzyme A (malonyl-CoA) is a critical precursor for the biosynthesis of a variety of biochemicals. It is synthesized by the catalysis of acetyl-CoA carboxylase (Acc1p), which was demonstrated to be deactivated by the phosphorylation of Snf1 protein kinase in yeast. In this study, we designe...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Chen, Xiaoxu, Yang, Xiaoyu, Shen, Yu, Hou, Jin, Bao, Xiaoming
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788913/
https://ncbi.nlm.nih.gov/pubmed/29422886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00047
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