Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Na(v)1.7 mutation that massively hyperpolarizes activation

Sodium channel Na(v)1.7 plays a central role in pain-signaling: gain-of-function Na(v)1.7 mutations usually cause severe pain and loss-of-function mutations produce insensitivity to pain. The Na(v)1.7 I234T gain-of-function mutation, however, is linked to a dual clinical presentation of episodic pai...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Huang, Jianying, Mis, Malgorzata A., Tanaka, Brian, Adi, Talia, Estacion, Mark, Liu, Shujun, Walker, Suellen, Dib-Hajj, Sulayman D., Waxman, Stephen G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788866/
https://ncbi.nlm.nih.gov/pubmed/29379075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20221-7
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