A novel gain-of-function Na(v)1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy

Voltage-gated sodium channel Na(v)1.7 is a threshold channel in peripheral dorsal root ganglion (DRG), trigeminal ganglion, and sympathetic ganglion neurons. Gain-of-function mutations in Na(v)1.7 have been shown to increase excitability in DRG neurons and have been linked to rare Mendelian and more...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Adi, Talia, Estacion, Mark, Schulman, Betsy R, Vernino, Steven, Dib-Hajj, Sulayman D, Waxman, Stephen G
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856981/
https://ncbi.nlm.nih.gov/pubmed/30392441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806918815007
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