Prior to Peripheral Tolerance, Newly Generated CD4 T Cells Maintain Dangerous Autoimmune Potential: Fas- and Perforin-Independent Autoimmunity Controlled by Programmed Death-1

Lymphopenia can result from various factors, including viral infections, clinical interventions, or as a normal property of the fetal/neonatal period. T cells in a lymphopenic environment undergo lymphopenia-induced proliferation (LIP) to fill the available “niche” as defined by peptide–MHC and home...

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Publicat a:Front Immunol
Autors principals: Ellestad, Kristofor K., Thangavelu, Govindarajan, Haile, Yohannes, Lin, Jiaxin, Boon, Louis, Anderson, Colin C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787554/
https://ncbi.nlm.nih.gov/pubmed/29416537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00012
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