Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2–Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells

Sulforaphane (SFN) is a natural product with cytoprotective, anti-inflammatory, and antioxidant effects. In this study, we evaluated the mechanisms of its effects on lipopolysaccharide (LPS)-induced cell death, inflammation, oxidative stress, and polarization in murine microglia. We found that SFN p...

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Vydáno v:Front Immunol
Hlavní autoři: Eren, Erden, Tufekci, Kemal Ugur, Isci, Kamer Burak, Tastan, Bora, Genc, Kursad, Genc, Sermin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787131/
https://ncbi.nlm.nih.gov/pubmed/29410668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00036
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