Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing

We hypothesized that dosing vancomycin to achieve trough concentrations of >15 mg/liter overdoses many adults compared to area under the concentration-time curve (AUC)-guided dosing. We conducted a 3-year, prospective study of vancomycin dosing, plasma concentrations, and outcomes. In year 1, non...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Neely, Michael N., Kato, Lauren, Youn, Gilmer, Kraler, Lironn, Bayard, David, van Guilder, Michael, Schumitzky, Alan, Yamada, Walter, Jones, Brenda, Minejima, Emi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786789/
https://ncbi.nlm.nih.gov/pubmed/29203493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02042-17
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