Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers

The objective of the study was to investigate the pharmacokinetic drug-drug interactions between tacrolimus (TAC) and mycophenolate mofetil (MMF) in healthy Korean male volunteers. Seventeen volunteers participated in a three-period, single-dose, and fixed sequence study. They sequentially received...

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Publicat a:Sci Rep
Autors principals: Kim, Jae Hyun, Han, Nayoung, Kim, Myeong Gyu, Yun, Hwi-Yeol, Lee, Sunhwa, Bae, Eunjin, Kim, Yon Su, Kim, In-Wha, Oh, Jung Mi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786104/
https://ncbi.nlm.nih.gov/pubmed/29374217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20071-3
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