Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients

This study quantifies the interaction between tacrolimus (TAC) and mycophenolate mofetil (MMF) in kidney transplant recipients. Concentrations of TAC, mycophenolic acid (MPA), and metabolites were analyzed and relevant genotypes were determined from 32 patients. A population model was developed to e...

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Vydáno v:Sci Rep
Hlavní autoři: Kim, Jae Hyun, Han, Nayoung, Kim, Myeong Gyu, Kim, Young Won, Jang, Hayoung, Yun, Hwi-Yeol, Yu, Mi-Yeon, Kim, In-Wha, Kim, Yon Su, Oh, Jung Mi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692323/
https://ncbi.nlm.nih.gov/pubmed/31409869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47876-0
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