Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

The molecular mechanism by which cancer-associated fibroblasts (CAFs) confer chemoresistance in ovarian cancer is poorly understood. The purpose of the present study was to evaluate the roles of CAFs in modulating tumor vasculature, chemoresistance, and disease progression. Here, we found that CAFs...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Leung, Cecilia S., Yeung, Tsz-Lun, Yip, Kay-Pong, Wong, Kwong-Kwok, Ho, Samuel Y., Mangala, Lingegowda S., Sood, Anil K., Lopez-Berestein, Gabriel, Sheng, Jianting, Wong, Stephen T.C., Birrer, Michael J., Mok, Samuel C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785271/
https://ncbi.nlm.nih.gov/pubmed/29251630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95200
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