A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

Guanylyl cyclase C (GCC) is a cell-surface protein that is expressed by normal intestinal epithelial cells, more than 95% of metastatic colorectal cancers (mCRC), and the majority of gastric and pancreatic cancers. Due to strict apical localization, systemically delivered GCC-targeting agents should...

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Vydáno v:PLoS One
Hlavní autoři: Gallery, Melissa, Zhang, Julie, Bradley, Daniel P., Brauer, Pamela, Cvet, Donna, Estevam, Jose, Danaee, Hadi, Greenfield, Edward, Li, Ping, Manfredi, Mark, Loke, Huay-Keng, Rabino, Claudia, Stringer, Brad, Williamson, Mark, Wyant, Tim, Yang, Johnny, Zhu, Qing, Abu-Yousif, Adnan, Veiby, O. Petter
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784926/
https://ncbi.nlm.nih.gov/pubmed/29370189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191046
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