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Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae

Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1 overexpression has mainly focused on the rat lesser epithelial ridge and induces ectopic hair cell regeneration. The sensory region of rat cochlea is difficult to transfect, thus new hair ce...

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Detalhes bibliográficos
Publicado no:Neural Regen Res
Main Authors: Luo, Wen-wei, Han, Zhao, Ren, Dong-dong, Wang, Xin-wei, Chi, Fang-lu, Yang, Juan-mei
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784360/
https://ncbi.nlm.nih.gov/pubmed/29323051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.221169
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