Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is an incurable childhood brain tumor. The mechanistic target of rapamycin (MTOR), a key oncogene, functions as two distinct signaling complexes, MTORC1 and MTORC2. We set out to determine the preclinical efficacy and mechanism of action of MTOR inhibitors in...

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Bibliografiset tiedot
Julkaisussa:Oncol Rep
Päätekijät: Flannery, Patrick C., Desisto, John A., Amani, Vladimir, Venkataraman, Sujatha, Lemma, Rakeb T., Prince, Eric W., Donson, Andrew, Moroze, Erin E., Hoffman, Lindsey, Levy, Jean M. Mulcahy, Foreman, Nicholas, Vibhakar, Rajeev, Green, Adam L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: D.A. Spandidos 2018
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783612/
https://ncbi.nlm.nih.gov/pubmed/29207163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2017.6122
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