The alkylating chemotherapeutic temozolomide induces metabolic stress in IDH1-mutant cancers and potentiates NAD+ depletion-mediated cytotoxicity

IDH1 -mutant gliomas are dependent upon the canonical coenzyme nicotinamide adenine dinucleotide (NAD+) for survival. It is known that Poly(ADP-ribose) polymerase (PARP) activation consumes NAD+ during base excision repair (BER) of chemotherapy-induced DNA damage. We therefore hypothesized that a st...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Tateishi, Kensuke, Higuchi, Fumi, Miller, Julie J., Koerner, Mara V.A., Lelic, Nina, Shankar, Ganesh M., Tanaka, Shota, Fisher, David E., Batchelor, Tracy T., Iafrate, A. John, Wakimoto, Hiroaki, Chi, Andrew S., Cahill, Daniel P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783559/
https://ncbi.nlm.nih.gov/pubmed/28625978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2263
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