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Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines

Emerging drug-resistance and drug-associated toxicities are two major factors limiting successful cancer therapy. Combinations of chemotherapeutic drugs have been used in the clinic to improve patient outcome. However, cancer cells can acquire resistance to drugs, alone or in combination. Resistant...

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Udgivet i:PLoS One
Main Authors: Maleki Vareki, Saman, Salim, Kowthar Y., Danter, Wayne R., Koropatnick, James
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783418/
https://ncbi.nlm.nih.gov/pubmed/29364966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191766
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