Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease

INTRODUCTION: Overt fibrostenotic disease is a relative contraindication for anti-TNF therapy in Crohn’s disease. We hypothesized that subclinical fibrosis may also contribute to an incomplete response to anti-TNF therapy before the onset of symptomatic stenosis. METHODS: In a previous trial, patien...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Bruyn, Jessica R., Becker, Marte A., Steenkamer, Jessica, Wildenberg, Manon E., Meijer, Sybren L., Buskens, Christianne J., Bemelman, Willem A., Löwenberg, Mark, Ponsioen, Cyriel Y., van den Brink, Gijs R., D’Haens, Geert R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783363/
https://ncbi.nlm.nih.gov/pubmed/29364909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190999
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