Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons

Chloride ions play an important role in controlling excitability of principal neurons in the central nervous system. When neurotransmitter GABA is released from inhibitory interneurons, activated GABA type A (GABA(A)) receptors on principal neurons become permeable to chloride. Typically, chloride f...

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Publicat a:eNeuro
Autors principals: Sørensen, Andreas T., Ledri, Marco, Melis, Miriam, Nikitidou Ledri, Litsa, Andersson, My, Kokaia, Merab
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2018
Matèries:
New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783240/
https://ncbi.nlm.nih.gov/pubmed/29379872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0172-17.2017
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