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Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2

A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [(3)H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and dopamine transporter (DAT), [(3)H]s...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Hankosky, Emily R., Joolakanti, Shyam R., Nickell, Justin R., Janganati, Venumadhav, Dwoskin, Linda P., Crooks, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782818/
https://ncbi.nlm.nih.gov/pubmed/29153425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.039
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