P08.41 Development of a novel TERT-targeting therapy for glioblastomas

INTRODUCTION: Approximately 60–80% of GBM harbour mutations in the promoter region of TERT that leads to its upregulation, making it the most common single genetic abnormalities in GBM. TERT, a reverse-transcriptase subunit of telomerase, has been an attractive candidate for therapy target because o...

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Vydáno v:Neuro Oncol
Hlavní autoři: Ichimura, K., Takahashi, M., Matsushita, Y., Maida, Y., Yasukawa, M., Hayashi, M., Hamada, A., Nishikawa, R., Narita, Y., Masutomi, K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
P08 Glioblastom and Anaplastic gliomas
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782670/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.174
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