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Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome

It is established that the physiological effects of insulin are primarily mediated by the insulin signaling pathway. However, a defective insulin signaling is closely associated with the clinical manifestations of polycystic ovary syndrome (PCOS), which include excess androgen levels, insulin resist...

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Dettagli Bibliografici
Pubblicato in:Mol Med Rep
Autori principali: Wang, Fan, Wang, Shaobing, Zhang, Zhenghong, Lin, Qingqiang, Liu, Yiping, Xiao, Yijun, Xiao, Kaizhuan, Wang, Zhengchao
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779901/
https://ncbi.nlm.nih.gov/pubmed/28990055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7678
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