Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials

Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active site and highly specific substrate of a bacterial...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Yang, Xinming, Koohi-Moghadam, Mohamad, Wang, Runming, Chang, Yuen-Yan, Woo, Patrick C. Y., Wang, Junwen, Li, Hongyan, Sun, Hongzhe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779714/
https://ncbi.nlm.nih.gov/pubmed/29320492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003887
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