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Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2

Commissural axons switch on responsiveness to Wnt attraction during midline crossing and turn anteriorly only after exiting the floor plate. We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Onishi, Keisuke, Zou, Yimin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779225/
https://ncbi.nlm.nih.gov/pubmed/28885142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25269
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