Lentivirus-mediated silencing of HOTAIR lncRNA restores gefitinib sensitivity by activating Bax/Caspase-3 and suppressing TGF-α/EGFR signaling in lung adenocarcinoma

Secondary resistance is a major limitation in the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment of lung cancer. Previous studies have shown that expression of the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is upregulated in lung cancer, which...

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Bibliographic Details
Published in:Oncol Lett
Main Authors: Liu, Yuanshun, Jiang, Hua, Zhou, Hongbin, Ying, Xiwang, Wang, Zhehua, Yang, Yang, Xu, Wulin, He, Xujun, Li, Yaqing
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2018
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778865/
https://ncbi.nlm.nih.gov/pubmed/29467862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7656
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