Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core he...

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Veröffentlicht in:Protein Cell
Hauptverfasser: Mimura, Yusuke, Katoh, Toshihiko, Saldova, Radka, O’Flaherty, Roisin, Izumi, Tomonori, Mimura-Kimura, Yuka, Utsunomiya, Toshiaki, Mizukami, Yoichi, Yamamoto, Kenji, Matsumoto, Tsuneo, Rudd, Pauline M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Higher Education Press 2017
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777974/
https://ncbi.nlm.nih.gov/pubmed/28597152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-017-0433-3
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