Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

Abstract Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to th...

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Detalhes bibliográficos
Main Authors: Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Roisin O’Flaherty, Tomonori Izumi, Yuka Mimura-Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto, Pauline M. Rudd
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2017-06-01
Colecção:Protein & Cell
Assuntos:
chemoenzymatic glycoengineering
crystal structure
endoglycosidase
fucose
glycosylation
intravenous immunoglobulin
Acesso em linha:http://link.springer.com/article/10.1007/s13238-017-0433-3
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