Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo

Breast cancer is the most prevalent malignancy in women and there is an urgent need for new therapeutic drugs targeting aggressive and metastatic subtypes, such as hormone-refractory triple-negative breast cancer (TNBC). Control of protein synthesis is vital to cell growth and tumour progression and...

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Опубликовано в: :Oncotarget
Главные авторы: Sesé, Marta, Fuentes, Pedro, Esteve-Codina, Anna, Béjar, Eva, McGrail, Kimberley, Thomas, George, Aasen, Trond, Ramón y Cajal, Santiago
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777738/
https://ncbi.nlm.nih.gov/pubmed/29383126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23145
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