Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology

Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the development of therapeutics, is an important task. SUMOylation is the posttranslational covalent attachment of proteins in the SUMO family (SUMO1,...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Hughes, David J., Tiede, Christian, Penswick, Natalie, Tang, Anna A. S., Trinh, Chi H., Mandal, Upasana, Zajac, Katarzyna Z., Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A., Duan, Jianxin, Feyfant, Eric, McPherson, Michael J., Tomlinson, Darren C., Whitehouse, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777597/
https://ncbi.nlm.nih.gov/pubmed/29138295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaj2005
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