KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer

PURPOSE: KRAS mutation is a common canonical mutation in CRC, found at differing frequencies in all Consensus Molecular Subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the immunobiological effects of KRAS mutation across the CMS spectru...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lal, Neeraj, White, Brian S, Goussous, Ghaleb, Pickles, Oliver, Mason, Mike J, Beggs, Andrew D, Taniere, Philippe, Willcox, Benjamin E, Guinney, Justin, Middleton, Gary W
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777581/
https://ncbi.nlm.nih.gov/pubmed/29061646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1090
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