Polarized macrophage subsets differentially express the drug efflux transporters MRP1 and BCRP, resulting in altered HIV production

INTRODUCTION: Macrophages play an important role in HIV, where they are a cellular reservoir. Macrophages are polarized into two phenotypes: pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages, which may have altered expression of drug efflux transporters, including BCRP and MRP1. T...

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Udgivet i:Antivir Chem Chemother
Main Authors: He, Hui, Buckley, Merrion, Britton, Bernard, Mu, Ying, Warner, Kristin, Kumar, Santosh, Cory, Theodore J
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777552/
https://ncbi.nlm.nih.gov/pubmed/29343083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206617745168
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