Down-regulation of human endogenous retrovirus type K (HERV-K) viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth

PURPOSE: We investigated the role of the human endogenous retrovirus type K (HERV-K) envelope (env) gene in pancreatic cancer (PC). EXPERIMENTAL DESIGN: shRNA was employed to knockdown (KD) the expression of HERV-K in PC cells. RESULTS: HERV-K env expression was detected in seven PC cell lines and i...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Li, Ming, Radvanyi, Laszlo, Yin, Bingnan, Li, Jia, Chivukula, Raghavender, Lin, Kevin, Lu, Yue, Shen, JianJun, Chang, David Z., Li, Donghui, Johanning, Gary L., Wang-Johanning, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777511/
https://ncbi.nlm.nih.gov/pubmed/28679769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0001
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