Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer

Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to...

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Vydáno v:Oncol Lett
Hlavní autoři: Nakajima, Takahiro, Okayama, Hirokazu, Ashizawa, Mai, Noda, Masaru, Aoto, Keita, Saito, Motonobu, Monma, Tomoyuki, Ohki, Shinji, Shibata, Masahiko, Takenoshita, Seiichi, Kono, Koji
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777280/
https://ncbi.nlm.nih.gov/pubmed/29434980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7556
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