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Sustained MAPK/ERK Activation in Adult Schwann Cells Impairs Nerve Repair

The MAPK/ERK pathway has a critical role in PNS development. It is required for Schwann cell (SC) differentiation and myelination; sustained embryonic MAPK/ERK activation in SCs enhances myelin growth overcoming signals that normally end myelination. Excess activation of this pathway can be maladapt...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cervellini, Ilaria, Galino, Jorge, Zhu, Ning, Allen, Shannen, Birchmeier, Carmen, Bennett, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777114/
https://ncbi.nlm.nih.gov/pubmed/29217688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2255-17.2017
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