Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma

STAT3 is constitutively activated in many cancers and regulates gene expression to promote cancer cell survival, proliferation, invasion, and migration. In diffuse large B cell lymphoma (DLBCL), activation of STAT3 and its kinase JAK1 is caused by autocrine production of IL-6 and IL-10 in the activa...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lu, Li, Zhu, Fen, Zhang, Meili, Li, Yangguang, Drennan, Amanda C., Kimpara, Shuichi, Rumball, Ian, Selzer, Christopher, Cameron, Hunter, Kellicut, Ashley, Kelm, Amanda, Wang, Fangyu, Waldmann, Thomas A., Rui, Lixin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776985/
https://ncbi.nlm.nih.gov/pubmed/29295936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715118115
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