Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release

Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs). Whereas in bacteria, RF1 and RF2 promote termination at UAA/UAG and UAA/UGA stop codons, respectively, eukaryotes only depend on one RF (eRF1) to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hoernes, Thomas Philipp, Clementi, Nina, Juen, Michael Andreas, Shi, Xinying, Faserl, Klaus, Willi, Jessica, Gasser, Catherina, Kreutz, Christoph, Joseph, Simpson, Lindner, Herbert, Hüttenhofer, Alexander, Erlacher, Matthias David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776981/
https://ncbi.nlm.nih.gov/pubmed/29298914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714554115
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