Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways

Cisplatin (CDDP) and doxorubicin (DOX) are chemotherapeutic drugs that trigger apoptosis by inducing DNA-damage. A previous study using breast cancer cells demonstrated the negative feedback modulation of the epidermal growth factor receptor (EGFR) and receptor tyrosine-protein kinase erbB-2 (ErbB2)...

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Bibliographic Details
Published in:Oncol Lett
Main Authors: Park, Chul Min, Kawasaki, Yuki, Refaat, Alaa, Sakurai, Hiroaki
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2018
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776949/
https://ncbi.nlm.nih.gov/pubmed/29434871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7532
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