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Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates

Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications worldwide in animals and humans. However, the toxicokinetics of DA have not been fully evaluated, and information is missing on the disposition of DA following oral exposures at doses that are considered safe for...

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Publicat a:Drug Metab Dispos
Autors principals: Jing, Jing, Petroff, Rebekah, Shum, Sara, Crouthamel, Brenda, Topletz, Ariel R., Grant, Kimberly S., Burbacher, Thomas M., Isoherranen, Nina
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776359/
https://ncbi.nlm.nih.gov/pubmed/29150543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.078485
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