Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis

Lymph nodes (LNs) are at the center of adaptive immune responses. Various exogenous substances are transported into LNs and a series of immune responses ensue after recognition by antigen–specific lymphocytes. Although humanized mice have been used to reconstitute the human immune system, most lack...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Takahashi, Takeshi, Katano, Ikumi, Ito, Ryoji, Goto, Motohito, Abe, Hayato, Mizuno, Seiya, Kawai, Kenji, Sugiyama, Fumihiro, Ito, Mamoru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776085/
https://ncbi.nlm.nih.gov/pubmed/29387068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.02017
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