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Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca(2+) Signaling

Excessive dynamin related protein 1 (Drp1)-triggered mitochondrial fission contributes to apoptosis under pathological conditions and therefore it has emerged as a promising therapeutic target. Mitochondrial division inhibitor 1 (mdivi-1) inhibits Drp1-dependent mitochondrial fission and is neuropro...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Ruiz, Asier, Alberdi, Elena, Matute, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776080/
https://ncbi.nlm.nih.gov/pubmed/29386996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00003
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