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CGP37157, an inhibitor of the mitochondrial Na(+)/Ca(2+) exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca(2+) channels
Inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca(2+) homeostasis. However, the Ca(2+) signaling pathways and stores underlying neuroprotection by that inhibitor are not well defined. In th...
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| Pubblicato in: | Cell Death Dis |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5424111/ https://ncbi.nlm.nih.gov/pubmed/24722281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.134 |
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