Elucidating the mechanism of the considerable mechanical stiffening of DNA induced by the couple Zn(2+)/Calix[4]arene-1,3-O-diphosphorous acid

The couple Calix[4]arene-1,3-O-diphosphorous acid (C4diP) and zinc ions (Zn(2+)) acts as a synergistic DNA binder. Silicon NanoTweezer (SNT) measurements show an increase in the mechanical stiffness of DNA bundles by a factor of >150, at Zn(2+) to C4diP ratios above 8, as compared to Zinc alone w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tauran, Yannick, Tarhan, Mehmet C., Mollet, Laurent, Gerves, Jean Baptiste, Kumemura, Momoko, Jalabert, Laurent, Lafitte, Nicolas, Byun, Ikjoo, Kim, Beomjoon, Fujita, Hiroyuki, Collard, Dominique, Perret, Florent, Desbrosses, Mickael, Leonard, Didier, Goutaudier, Christelle, Coleman, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775194/
https://ncbi.nlm.nih.gov/pubmed/29352239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19712-4
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