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The structure of glucose‐1‐phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA‐type enzymes

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, continues to be a major threat to populations worldwide. Whereas the disease is treatable, the drug regimen is arduous at best with the use of four antimicrobials over a six‐month period. There is clearly a pressing need for the devel...

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Publicat a:Protein Sci
Autors principals: Brown, Haley A., Thoden, James B., Tipton, Peter A., Holden, Hazel M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775166/
https://ncbi.nlm.nih.gov/pubmed/29076563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3333
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