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The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA)
The synthesis of deoxy-thymidine di-phosphate (dTDP)–l-rhamnose, an important component of the cell wall of many microorganisms, is a target for therapeutic intervention. The first enzyme in the dTDP–l-rhamnose biosynthetic pathway is glucose-1-phosphate thymidylyltransferase (RmlA). RmlA is inhibit...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305900/ https://ncbi.nlm.nih.gov/pubmed/11118200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.24.6652 |
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