Chemical proteomics reveals soluble epoxide hydrolase as a therapeutic target for ocular neovascularization

The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling. There are currently no FDA approved small molecules for treating these blinding eye diseases. There...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sulaiman, Rania S., Park, Bomina, Babu, Sardar Pasha Sheik Pran, Si, Yubing, Kharwadkar, Rakshin, Mitter, Sayak K., Lee, Bit, Sun, Wei, Qi, Xiaoping, Boulton, Michael E., Meroueh, Samy, Fei, Xiang, Seo, Seung-Yong, Corson, Timothy W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775043/
https://ncbi.nlm.nih.gov/pubmed/29193961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00854
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