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Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals

Non-uniform shortening of the action potential duration (APD(90)) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia. This study examined whether spatial heterogeneities in APD(90) restitution can be amplified by drugs with c...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
1. Verfasser: Osadchii, Oleg E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774816/
https://ncbi.nlm.nih.gov/pubmed/29352276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191514
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