Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy

BACKGROUND: Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. METHODS: Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, b...

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Publicat a:PLoS One
Autors principals: Yakabe, Mitsutaka, Ogawa, Sumito, Ota, Hidetaka, Iijima, Katsuya, Eto, Masato, Ouchi, Yasuyoshi, Akishita, Masahiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774788/
https://ncbi.nlm.nih.gov/pubmed/29351340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191318
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